Abstract
BackgroundReference data for plasma lipids and blood pressure are not available for Asian Indian adolescents. This study aimed to develop representative age- and sex- specific percentile reference data for serum lipids [total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol] and blood pressure for urban Asian Indian adolescents aged 14–18 years. The sample consisted of 680 boys and 521 girls aged 14–18 years from the cross-sectional population survey, Epidemiological Study of Adolescents and Young Adults (ESAY) for whom the data for serum lipid levels and blood pressure were recorded. Smoothed age- and sex- specific 5th, 10th, 25th, 50th, 75th, 85th, 90th and 95th percentiles where derived using LMS regression.ResultsPercentile-based reference data for serum lipids and blood pressure are presented for adolescent Asian Indian boys and girls for the first time. Asian Indian adolescents had lower levels of serum TC, LDL-C and HDL-C and higher TG than their counterparts in the USA. Interesting trends in TC and HDL-C levels where observed, which might reflect changes in dietary pattern and physical activity in this age group in India.ConclusionThese reference data could be used to identify adolescents with an elevated risk of developing dyslipidemia, hypertension and cardiovascular disorders, to plan and implement preventive policies, and to study temporal trends.
Highlights
Atherosclerosis begins in childhood and progresses to coronary heart disease (CHD) in adults [1]
We have recently reported that insulin resistance and low levels of high density lipoprotein cholesterol (HDL-C) are common in Asian Indian adolescents, portending high risk for development of CHD in adults [13,14]
Smoothed age- and sex- specific cut-offs of serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), HDL-C, TG, non-HDL-C, systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the 5th, 10th, 25th, 50th, 75th, 85th, 90th, and 95th percentiles are presented in tables 2, 3, 4, 5, 6, 7, 8
Summary
Atherosclerosis begins in childhood and progresses to coronary heart disease (CHD) in adults [1]. Lipids in Health and Disease 2005, 4:20 http://www.lipidworld.com/content/4/1/20 Age (y) n TC (mg/dl) LDL-C(mg/dl) TG (mg/dl) HDL-C (mg/dl) SBP (mmHg) DBP(mmHg). TC, Total cholesterol; LDL-C, Low-density lipoprotein cholesterol; TG, Triglycerides; HDL-C, High-density lipoprotein cholesterol; SBP, Systolic blood pressure; DBP, Diastolic blood pressure. Reference data for plasma lipids and blood pressure are not available for Asian Indian adolescents. This study aimed to develop representative age- and sex- specific percentile reference data for serum lipids [total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol] and blood pressure for urban Asian Indian adolescents aged 14–18 years. The sample consisted of 680 boys and 521 girls aged 14–18 years from the cross-sectional population survey, Epidemiological Study of Adolescents and Young Adults (ESAY) for whom the data for serum lipid levels and blood pressure were recorded. Smoothed age- and sex- specific 5th, 10th, 25th, 50th, 75th, 85th, 90th and 95th percentiles where derived using LMS regression
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