Abstract

The Center of Biomedical Research Excellence in Matrix Biology strives to improve our understanding of extracellular matrix at molecular, cellular, tissue, and organismal levels to generate new knowledge about pathophysiology, normal development, and regenerative medicine. The primary goals of the Center are to i) support junior investigators, ii) enhance the productivity of established scientists, iii) facilitate collaboration between both junior and established researchers, and iv) build biomedical research infrastructure that will support research relevant to cell–matrix interactions in disease progression, tissue repair and regeneration, and v) provide access to instrumentation and technical support. A Pilot Project program provides funding to investigators who propose applying their expertise to matrix biology questions. Support from the National Institute of General Medical Sciences at the National Institutes of Health that established the Center of Biomedical Research Excellence in Matrix Biology has significantly enhanced the infrastructure and the capabilities of researchers at Boise State University, leading to new approaches that address disease diagnosis, prevention, and treatment. New multidisciplinary collaborations have been formed with investigators who may not have previously considered how their biomedical research programs addressed fundamental and applied questions involving the extracellular matrix. Collaborations with the broader matrix biology community are encouraged.

Highlights

  • The purpose of this article is to inform the extracellular matrix (ECM) biology research community about the establishment of a new center for matrix biology research that can serve as a resource for investigators interested in disease-related and developmental biology aspects of matrix biology research

  • During Phase I, the program provided the opportunity to build infrastructure for biomedical research and to link researchers from multiple disciplines to carry out convergent science in research areas that are important to the ECM research community

  • Assessment is essential for the evaluation of the Centers of Biomedical Research Excellence (COBRE) program as a whole, individual researchers, research infrastructure, faculty development, and how well the COBRE enables researchers to attain independent grant support

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Summary

Introduction

The purpose of this article is to inform the extracellular matrix (ECM) biology research community about the establishment of a new center for matrix biology research that can serve as a resource for investigators interested in disease-related and developmental biology aspects of matrix biology research. The National Institutes of Health (NIH) Centers of Biomedical Research Excellence (COBRE) program strengthens biomedical or behavioral research capacity in institutions from Institutional Development Award (IDeA)-eligible states. COBRE Phase I provides support to develop research infrastructure and to foster independence of junior investigators. COBRE Phase II continues the progress toward building an independent research center that is competitive for support from NIH or other funding agencies. The COBRE Phase III awards (Transitional Centers) provide support for maintaining COBRE research cores developed during phases I and II that are essential for ongoing basic, clinical, translational, and/or community-based research at the institution. A key role for Phase III awards is to sustain a collaborative, multidisciplinary research environment for research pilot projects as well as mentoring and training opportunities

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