Abstract
Censored at the Nanoscale.
Highlights
Cell-to-cell communication has been documented in biofilm dispersal leading to further propagation of biofilms within these systems (Solano et al, 2014)
Many efforts to interrupt and quench quorum-sensing have exploited the knowledge of signaling systems using specific model organisms, most notably Pseudomona aeruginosa, Staphylococcus aureus, and Vibrio fischeri (Stevens and Greenberg, 1997; Miller and Bassler, 2001; Schuster and Greenberg, 2006; Novick and Geisinger, 2008)
In a recent Frontiers in Microbiology article, Miller et al (2015) introduce a different and unique approach that exploited the slightly-hydrophobic core of a beta-cyclodextrin (β-CD) to non- bind homoserine lactones (HSLs), and quench the signaling between V. fischeri cells
Summary
Many efforts to interrupt and quench quorum-sensing have exploited the knowledge of signaling systems using specific model organisms, most notably Pseudomona aeruginosa, Staphylococcus aureus, and Vibrio fischeri (Stevens and Greenberg, 1997; Miller and Bassler, 2001; Schuster and Greenberg, 2006; Novick and Geisinger, 2008). Specific approaches have been developed to target and block gene-regulation or to inactivate receptor proteins, these approaches may have limited effects in mixed-community biofilms. Non-specific quenching of quorum-sensing molecules may have broader impact.
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