CENPE promotes lung adenocarcinoma proliferation and is directly regulated by FOXM1.

Abstract

Lung cancer is the most common and most lethal type of cancer. A sustained proliferative capacity is one of the hallmarks of cancer, and microtubules serve an important role in maintaining a sustained cell cycle. Therefore, understanding the regulation of microtubule proteins in the cell cycle is important for tumor prevention and treatment. Centromere proteinE(CENPE) is a human kinetochore protein that is highly expressed in the G2/Mphase of the cell cycle. The present study identified that CENPE is highly expressed in lung adenocarcinoma(LUAD) tissues. Following knockdown of CENPE expression, the proliferation of lung cancer cells was inhibited. In addition, it was revealed that forkhead boxM1 (FOXM1) is significantly correlated with CENE expression. Following FOXM1‑knockdown, the expression level of CENPE was decreased and the proliferation of lung cancer cells was inhibited. Overexpression of FOXM1 promoted the expression of CENPE and the proliferation of lung cancer cells. A chromatin immunoprecipitation assay identified that FOXM1 binds directly to the promoter region of CENPE. Therefore, the present data demonstrated that CENPE can promote the proliferation of LUAD cells and is directly regulated by FOXM1.