Abstract
China has different ethnic minorities that establish their own medical systems and practice experience for thousand years, thereafter named Chinese Ethnic Minority Traditional Drugs (CEMTDs) (http://www.cemtdd.com/index.html). Since many compounds from CEMTDs have been reported to perturb human's dysfunction network and restore human normal physiological conditions, the relationships amongst a series of compounds from specific herbs, their targets and relevant diseases have become our main focus in CEMTD modernization. Herein, we have constructed the first Chinese Ethnic Minority Traditional Drug Database (CEMTDD) mainly from Xinjiang Uygur Autonomous Region (XUAR), retrieving CEMTD-related information from different resources. CEMTDD contains about 621 herbs, 4, 060 compounds, 2, 163 targets and 210 diseases, among which most of herbs can be applied into gerontology therapy including inflammation, cardiovascular disease and neurodegenerative disease. Gerontology is highly occurred in XUAR, and has abundant experience in treating such diseases, which may benefit for developing a new gerontology therapeutic strategy. CEMTDD displays networks for intricate relationships between CEMTDs and treated diseases, as well as the interrelations between active compounds and action targets, which may shed new light on the combination therapy of CEMTDs and further understanding of their herb molecular mechanisms for better modernized utilizations of CEMTDs, especially in gerontology.
Highlights
Chinese Ethnic Minority Traditional Drugs (CEMTDs), originated from different nations in China, have been widely used as therapeutic regimen for thousands of years [1]
CEMTDs are basically based upon some unpopular theories in the minority area, which are different from the philosophy of both modern western medicine and traditional Chinese medicine (TCM); thereby, they are largely prevented from being recognized by the mainland of China
Different nations from China have had their own biomedical theories and systems, and the empirical evidence-based theories and systems have contributed a lot to the health of Chinese minority people; thereby, medical resource from nature is our huge treasure
Summary
Chinese Ethnic Minority Traditional Drugs (CEMTDs), originated from different nations in China, have been widely used as therapeutic regimen for thousands of years [1]. In the past few decades, some Chinese scientists have made their great efforts to explore various CEMTDs and decompose their isolated bioactive compounds, in which different action targets are identified These findings may provide precious resources and useful guidance for developing and utilizing CEMTDs to treat human diseases at the system level. Current strategy for drug discovery is mainly focusing on the “one gene-one drug-one disease” code, which has caused limitations since the drug’s efficacy is impaired by the robustness of protein-protein interaction (PPI) network in the treated objectives [6] To overcome such limitations, there is an urgent need to use systemsoriented approaches for effective combinatorial drugs. Turning to CEMTDs may be a sensible solution because they may treat diverse diseases in a holistic way
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