Abstract
Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8–24 μM.
Highlights
Soft corals of the genus Lobophytum have proven to be a rich source of structurally diverse diterpenes, especially macrocyclic cembranoids characterized by their14-membered carbocyclic skeleton
Locrassumin assigned a molecular formula of C22
nitric oxide (NO) production in mouse peritoneal macrophages with IC50 values of 8–24 μM. These results add to a growing class of diverse cembranoid structures that are known to inhibit NO production
Summary
Soft corals of the genus Lobophytum (family Alcyoniidae) have proven to be a rich source of structurally diverse diterpenes, especially macrocyclic cembranoids characterized by their. In the course of our investigation of bioactive substances produced by marine invertebrates from the South China Sea [25,26,27], a specimen of L. crassum was collected. Chemical examination of this specimen led to the isolation of. This paper reports details of the isolation, structure biological evaluation of macrophages (PEMФ). This paper reports details of theelucidation, isolation, and structure elucidation, and these compounds.
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