Abstract
A molecular docking analysis has been carried out on several cytotoxic cembaranoid type diterpenes that have been isolated from soft coral Sarcophyton glaucum i.e sarcophytolol, sarcophytolide B, sarcophytolide C, sarcophine, deoxosarcophine, and cembrene C. All the compounds were investigated using in silico molecular docking with several enzymes and receptor protein targets i.e cyclin-dependent protein kinase 2 (CDK-2), cyclin-dependent protein kinase 6 (CDK-6), protein kinase C (PKC), vascular endothelial growth factor receptor 2 (VEGFR-2), DNA topoisomerase II and tubulin, in order to investigate the potential molecular targets and to correlate the experimental cytotoxicity of these cembranoid compounds. Molecular docking revealed that sarcophytolol C and deoxosarcophine docked strongly into podophylotoxin binding site of tubulin receptor while the other compounds exhihited selectivity for protein kinase C. The variation of experimental inhibition of concentration (IC50) on several cancer cell lines might be due to the difference mechanism of actions of these cembranoid compounds.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
