Abstract
An efficient method for the synthesis of new heteroaryl substituted dihydropyridine derivatives via a one-pot four-component coupling reaction of heteroaldehyde, 1,3-diketone, ethylacetoacetate, and amonium acetate in the presence of cellulose-sulfuric acid as a biosupported solid acid catalyst was developed. The reaction gave the new derivatives of fused 1,4-dihydropyridines in lower reaction times and excellent yields (85–95%).
Highlights
1,4-Dihydropyridines exhibit interesting pharmacological and biological properties
Many methods have been reported for the synthesis of 1,4-dihydropyridine derivatives in view of the biological importance associated with these compounds
Melting points were measured on an electrothermal 9100 apparatus and are uncorrected. 1H NMR spectra were obtained on a Bruker DRX-500 Avance spectrometer, and 13C NMR spectra were obtained on a Bruker DRX-125 Avance spectrometer
Summary
1,4-Dihydropyridines exhibit interesting pharmacological and biological properties. They have been used as calcium channel modulators for the treatment of cardiovascular disorders [1, 2]. They present vasodilating [3], antifilarial [4], and antitubercular activities [5] and may serve as NADH mimics [6, 7]. Many methods have been reported for the synthesis of 1,4-dihydropyridine derivatives in view of the biological importance associated with these compounds. Development of a simple, efficient, and versatile method for preparation of new derivatives of 1,4dihydropyridine is a great challenge
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