Cellulose nanocrystals as an innovative superdisintegrant for oral dispersible tablets

Abstract

Oral Dispersible Tablets (ODTs), designed for rapid disintegration in the oral cavity, offer advantages such as easy administration for diverse populations and faster drug absorption. Microcrystalline cellulose (MCC) has been a traditional choice as a disintegrant, but its limitations have led to increased interest in cellulose nanocrystals (CNCs). This study focuses on obtaining and characterizing CNCs derived from MCC by sulfuric acid hydrolysis, exploring different times and drying methods (lyophilization or spray drying). At a 50 % v/v acid concentration for 60 min at 45 °C it was possible to extract CNC with a 76 % yield. When lyophilized, CNC micrographs showed large aggregates with few isolated particles, while the spray-dried samples were seen as free, elongated particles. The resulting CNCs, with enhanced properties like high hydrophilicity and surface area, are investigated for their impact on ODT formulations. All of them disintegrated faster than 10 s. A comprehensive analysis of ODTs' disintegration mechanism was also undertaken. The drying method dictates the predominant disintegration mechanism, even though this is also influenced by the nanoparticle size. Therefore, the study contributes insights into the potential of CNCs as innovative superdisintegrants, offering a promising path for improving oral drug delivery systems.