Abstract

The objective of the current work is to develop a new co-processed excipient based on cellulose nanocrystals and investigate its pharmaceutical excipient properties. Cellulose nanocrystals were isolated from the pseudostem of Musa balbisiana, following TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-mediated oxidation, and then co-processed with potato starch by the wet granulation method. Physicochemical properties, including the flow property, consolidation characteristics and rate of consolidation, were investigated, and a Kawakita plot was also generated. The compressibility, compactibility and tabletability of the novel excipient were determined. The equivalent circle diameter of the excipient particle was calculated as 4.09±0.90 μm, exhibiting a fair to passable flow property. The mean yield pressure from the Heckel plot was found to be 82.64 MPa, indicating its ability to undergo plastic deformation at relatively lower compression pressures. When compared to sodium starch glycolate, a standard tablet disintegrant, the cellulose nanocrystal-based co-processed excipient produced better dissolution of the model drug paracetamol.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.