Abstract
The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its dissolution difficulty, there are no known physiologically relevant or pharmaceutically clinical applications for this polymer. Thus, research is underway on controlled and adjusted forms of cellulose depolymerization.To advance the study of applying CM for tissue engineering, we have suggested new possibilities for electron beam (E-beam) treatment of CM. Treatment of CM with an E-beam can modify physical, chemical, molecular and biological properties, so it can be studied continuously to improve its usefulness and to enhance value.We review clinical applications of CM, cellulose binding domains, cellulose crosslinking proteins, conventional hydrolysis of cellulose, and depolymerization with radiation and focus our experiences with depolymerization of E-beam irradiated CM in this article.
Highlights
Electron beam irradiation (EBI), known as electron beam (E-beam) processing, is a process that uses electrons, usually of high energy, to treat objects for purposes such as sterilization and crosslinking of polymers
To advance the study of applying E-beam irradiated cellulose membrane (CM) for tissue engineering approaches, here, we suggest new possibilities for EBI treatment of CM
We previously demonstrated that CM can be successfully used as a guided bone regeneration (GBR) membrane in combination with particulate bone grafting and that the peculiar characteristics of E-beam irradiated CM are useful for space maintenance and biocompatibility [2, 5, 10, 11]
Summary
Electron beam irradiation (EBI), known as electron beam (E-beam) processing, is a process that uses electrons, usually of high energy, to treat objects for purposes such as sterilization and crosslinking of polymers. The application of natural polymers for medical or environmental purposes necessitates the use of these polymers in crosslinking hydrogels [18] or the chain scissioning with exposure to high energy radiation [14, 19]. The removal of CBD from the enzyme results in decreased affinity and much reduced hydrolytic activity on crystalline cellulose.
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