Cellulose Functionalysed with Grafted Oligopeptides

Abstract

Advantages offered by immobilization of any component of the reacting system are rewarding all additional efforts and the cost of the support. The majority of the methods reported have been based on the principles of solid phase organic synthesis (SPOS) in which the substrate is attached to the polymer support and excesses of reactants and reagents used to drive each synthetic step to completion. Then simple filtration affords a polymer bound product. While this approach is undoubtedly effective, there are a number of drawbacks which include the requirement for additional chemical steps to attach starting material, to develop synthetic methodology for the solid phase and to cleave products. More recently, solution phase methods, which circumvent these difficulties, have been introduced as alternatives to SPOS. These allow the use of excess of reagents followed by sequestrating either the product or excess reagents and byproducts from the reaction mixture using an insoluble functionalized polymer. Isolation and purification can then be achieved by simple filtration and evaporation.