Abstract
We reported the studies of aggregation, cellular uptake and cytotoxicity of C 60(OH) x , one of important water-soluble fullerene derivatives. The results showed C 60(OH) x was smaller in size but harder to go into cells in the media with serum. Moreover, C 60(OH) x showed severe toxicity to Chinese hamster lung and Chinese hamster ovary cells, but almost no effect on L929 cells, which implied that the cytotoxicity of C 60(OH) x was cell type specific. Flow cytometry was used to examine the precise effect of C 60(OH) x on the cell cycle and found cells was blocked at G1 phase. These results are expected to be helpful to understand the toxicity of fullerene derivatives.
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