Abstract
In this study, we investigated the antioxidative and antiaging activity of Perilla frutescens using LLC-<TEX>$PK_1$</TEX> porcine renal epithelial cell and WI-38 human diploid fibroblast cell. The extract from Perilla frutescens showed strong protective effect against nitric oxide (NO) and superoxide (<TEX>$O_2{^-}$</TEX>)-induced oxidative stress generated by sodium nitroprusside (SNP) and pyrogallol, respectively. The result showed that P. frutescens increased the cell viability and showed scavenging activity of NO and <TEX>$O_2{^-}$</TEX>. In addition, the extract of P. frutescens exerted the protective effect against peroxynitrite (<TEX>$ONOO^-$</TEX>) induced by 3-morpholinosydnonimine. It suggests that P. frutescens would have the protective role against <TEX>$ONOO^-$</TEX> itself and its precursors, NO and <TEX>$O_2{^-}$</TEX>. Furthermore, the aging model of hydrogen peroxide (<TEX>$H_2O_2$</TEX>)-treated WI-38 human diploid fibroblast was employed to investigate the anti-aging effect of P. frutescens. <TEX>$H_2O_2$</TEX>-treated WI-38 cells showed the loss of cell viability, however before-treatment with P. frutescens to WI-38 cells under premature senescence could delay the cellular aging process. The present study suggests the antioxidative and antiaging potential against free radical-induced oxidative damage of P. frutescens.
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