Abstract
Cellular stress responses in cancer and cancer therapy.
Highlights
The Research Topic titled “Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications” features 11 articles that reflect the broadness and complexity of the processes induced by cellular stress
It begins with reviews on four different proteins/protein families that are critical for cellular stress responses and as such are important for both cancer development and the response to cytotoxic therapies
Knippschild and colleagues discuss the complex functions of the casein kinase 1 (CK1) family and describe in depth how members of this family regulate signaling cascades that are relevant for the pathogenesis of inflammatory and proliferative diseases and, beyond this, for neurodegenerative disorders as well
Summary
The Research Topic titled “Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications” features 11 articles that reflect the broadness and complexity of the processes induced by cellular stress. It begins with reviews on four different proteins/protein families that are critical for cellular stress responses and as such are important for both cancer development and the response to cytotoxic therapies. Other post-translational modifications are an effective means to modify the activity of cellular proteins and respond to stress signals.
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