Cellular Signaling and Innate Immune Responses to RNA Virus Infections

Abstract

Table of Contents I. Introduction 1.Introduction and Overview, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon II. Antiviral Signaling Pathways and Their Contributions to Virus Control and Pathogenesis 2.Role of Toll-Like Receptors in the Innate Immune Response to RNA Viruses, Sinead E. Keating and Andrew G. Bowie 3. Cytoplasmic Pattern Receptors and Signaling in Viral Infections, Osamu Takeuchi and Shizuo Akira 4. Mitochondrial Antiviral Signaling, Vijay G. Bhoj and Zhijian J. Chen 5. Interferon Regulatory Factors and the Atypical IKK-Related Kinases TBK1 and IKK[e]: Essential Players in the Innate Immune Response to RNA Virus Infection, Meztli Arguello, Suzanne Paz, and John Hiscott 6. Jak-Stat Pathway in Response to Virus Infection, Joan E. Durbin 7. Interferons and Antiviral Action, Christine L. White and Ganes C. Sen 8. The Nuclear Factor-[k]B Transcription Factor Pathway, Amer A. Beg and Xingyu Wang 9. The Nuclear Factor-[k]B Signaling Network: Insights from Systems Approaches, Allan R. Brasier 10. Type I Interferon Signaling in Shaping Cellular Innate and Adaptive Immunity to Viral Infection, Christine A. Biron 11. Biological Impact of Type I Interferon Induction Pathways beyond Their Antivirus Activity, Bahram Razani, Arash Shahangian, Beichu Guo, and Genhong Cheng 12. Human Genetic Factors Involved in Viral Pathogenesis, Lennart Svensson and Elin Kindberg III. Activation and Evasion of Host Antiviral Signaling Pathways by RNA Viruses 13. RNA Virus Families: Distinguishing Characteristics, Differences, and Similarities, Peter W. Mason and Frank Scholle 14. Rhabdoviruses and Mechanisms of Type I Interferon Antagonism, Krzysztof Brzozka and Karl-Klaus Conzelmann 15. Filoviruses, Christopher F. Basler 16. Inhibition of Antiviral Signaling Pathways by Paramyxovirus Proteins, Antonella Casola, Xiaoyong Bao, Allan R. Brasier, and Roberto P. Garofalo 17. Suppression of Innate Immunity by Orthomyxoviruses, Randy A. Albrecht and Adolfo Garcia-Sastre 18. Bunyaviruses and Innate Immunity, Friedemann Weber and Richard M. Elliott 19. Arenaviruses, Juan C. de la Torre 20. Regulation of Innate Immunity by the Flaviviridae, Brenda L. Fredericksen and Michael Gale, Jr. 21. Evasion of Innate Host Antiviral Defenses by Picornaviruses, Stanley M. Lemon 22. Togaviruses, William B. Klimstra and Kate D. Ryman 23. Coronaviruses and Arteriviruses, Krishna Narayanan and Shinji Makino 24. Caliciviridae and Astroviridae, Susana Guix and Mary K. Estes 25. Innate Immune Responses Elicited by Reovirus and Rotavirus, Barbara Sherry, John T. Patton, and Terence S. Dermody IV. Summary and Perspectives 26. Summary and Perspectives, Allan R. Brasier, Adolfo Garcia-Sastre, and Stanley M. Lemon