Cellular Response of Cancer to Music: Mirror, Mirror, on the Wall, Which is the Most Effective of Them All?

Abstract

Aim: Cancer is one of the most common health problems in the world. Music is a therapy method that creates positive changes in human behavior. This study aims to examine the effects of Turkish and Western classical music on MCF-7, SKOV-3, PC-3, U87, and COLO741 cancer cell lines. Material and Methods: Group 1: No sound, Group 2: Turkish classical music (ney), Group 3: Western classical music (piano), and Group 4: Western classical music (violin). After listening to the cancer cells for 40 min, the audio files were interrupted for 1h, and then music was played for another 40 min. The effect of music on the proliferation of cancer cells was determined by WST-1 cell viability analysis. Statistical analyzes were performed with the SPSS program. Results: There was no statistically significant difference between the groups that were applied music once in only the MCF-7 breast cancer cells and the control group (p>0.05). A statistically significant decrease was detected in cell viability when the control group and the other groups that were applied to music twice were compared (p<0.05). For other cancer cell lines except (please the SKOV-3 ovarian cancer cells, it was determined that music application once also caused a statistically significant decrease in cell viability (p<0.05). Conclusion: We determined that classical music effectively reduced and suppressed the number of cancer cells. According to the data, Turkish and Western classical music can be used to support the treatment in of cancer patients.