Abstract
Summary Cellular repopulation of thymus and bone marrow was investigated in mice after X-irradiation. The animals had either one leg shielded during irradiation for varying lengths of time, or were transplanted with syngeneic bone marrow cells in graded numbers immediately after radiation treatment. During the first 12 days after treatment thymic repopulation was largely independent of the number of bone marrow cells available in the organism. Thereafter repopulation proceeded in relation to the number of the bone marrow cells present. In contrast to the thymus, cellular restoration of the bone marrow was directly related to the number of the protected or transplanted marrow cells from the beginning. An indirect effect of radiation on the regeneration pattern of the population of small size bone marrow cells, comprising largely lymphoid elements, was noted.
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