Abstract
The relative concentrations of lymphocytes and reticular epithelial cells in rat thymus were assessed quantitatively during the first 8 weeks after birth. There was an inverse relationship between the concentration of the two types of cells. The mitotic index of lymphocytes was lower at the highest and lowest lymphocyte densities compared with that at intermediate cell densities. The mean mitotic index decreased from three to eight weeks of age but on the whole the same patterns of mitotic index in relation to cell density were found at all ages. It is thought that these quantitative relationships may be an indication that a density dependent type of intercellular control system governs the two cell populations and that the setting of this changes with age.
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