Abstract
We report here on the nuclear penetration capability besides the excellent cellular uptake property of the fluorescent monodisperse mesoporous silica nanospheres (FMMSN) prepared by a bioinspired silicification route. The FMMSNs show great potential as efficient and stable intracellular labeling agents in human cervical cancer cells and various human mesenchymal stem cells. The advantages of these nanoparticles for biological applications are reflected in eliminating additional steps generally required for functionalisation or modification of the silica particles to make them efficient for cellular internalisation, fluorescent and biocompatible. The presence of polyamine by virtue of the biomineralisation process makes the FMMSN highly dispersible in water and at the same time facilitates the cellular and nuclear internalisation of FMMSNs. A detailed study on the cellular uptake properties of FMMSNs under various pharmacological inhibitors reveals that the internalisation of these nanoparticles occurs mainly via clathrin-mediated endocytosis mechanism.
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