Abstract
Idiopathic (thyroid-associated) ophthalmopathy is an autoimmune disorder of the extraocular muscles and orbital connective tissue (1-3). It is associated with Graves 1 hyperthyroidism in 80% of cases and Hashimoto’s thyroiditis in 20%. Although a variety of antibodies against eye muscle (EM) and orbital connective tissue (OCT) antigens have been demonstrated (4-6) their role in the tissue damage of ophthalmopathy is unclear. We have recently identified antibodies which are cytotoxic to EM cells in antibody dependent cell-mediated cytotoxicity (ADCC), some of which cross-reacted with surface antigens on thyroid cells and orbital fibroblasts (7). The role of cellular immune mechanisms in the autoimmune reactions against eye muscle and OCT has not been extensively studied (reviewed in 8).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
