Abstract
In rat brain, the cellular localization of a phosphoinositide-linked metabotropic glutamate receptor (mGluR1α) was demonstrated using antibodies that recognize the C-terminus of the receptor. mGluR1α, a 142 kd protein, is enriched within the olfactory bulb, stratum oriens of CA1 and polymorph layer of dentate gyrus in hippocampus, globus pallidus, thalamus, substantia nigra, superior colliculus, and cerebellum. Lower levels of mGluR1α are present within neocortex, striatum, amygdala, hypothalamus, and medulla. Dendrites, spines, and neuronal cell bodies contain mGluR1α. mG1uR1α is not detectable in presynaptic terminals. mGluR1α and ionotropic a-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits show differential distributions, but in Purkinje cells, mGluR1α and specific AMPA receptor subunits colocalize. The postsynaptic distribution of mGluR1α is consistent with postulated physiological roles of this subtype of glutamate receptor.
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