Abstract
The influence of bacterial endotoxins on the cellular kinetics of 19S and 7S hemolysin production was studied in mice. The following results were obtained: As compared to the primary immunization of mice with sheep red blood cells, the additional injection of endotoxin caused a significant increase of the spleen weight and an accelerated and prolonged multiplication of 19S and 7S hemolysin-forming spleen cells. Accordingly, 7S hemolysin titers were higher and persisted for a longer period of time. In mice treated with endotoxin only, a moderate elevation of the numbers of pre-existing 19S hemolysin-forming spleen cells was detectable, whereas 7S producers could not be found.
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