Abstract
The possibility of a link between parathyroid hyperfunction and cellular immune functions was studied in primary hyperparathyroid (1°HP) patients. The effect of cimetidine on lymphocyte functions in 1°HP patients and control subjects was also investigated. Histamine-induced suppressor activity of lymphocytes from 1°HP patients was significantly greater than that of controls. Cimetidine addition to both normal and 1°HP lymphocyte cultures abolished histamine-induced suppression. In vivo administration of cimetidine, while ineffective towards normal lymphocytes, depressed phytohemagglutinin stimulation of 1°HP lymphocytes, indicating possible immunological damage caused by this drug, which is frequently used in the treatment of patients with 1°HP.
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