Abstract
This chapter discusses the control of cellular glucose-sensing pathways and energy metabolism. Genetic and biochemical studies of Saccharomyces cerevisiae underscore the importance of glucose-sensing pathways and cellular energy metabolism in aging. The connection between cellular responses to states of glucose/nutrient deprivation and aging is intriguing. Most organisms in the biosphere have evolved the mechanisms that permit them to adapt to episodic and extended periods of nutrient deprivation. It is tempting to speculate that early in the course of evolution, development of these adaptive mechanisms laid the foundations for pathways that also effect cellular senescence. Extracellular glucose is detected by yeast through multiple glucose-sensing pathways. The effects of genetic manipulations of SNF3 and RGT2 on yeast aging are yet to be reported, there is evidence that at least two other glucose sensing pathways modulate replicative senescence. The pathways like Snf1, that regulate glucose sensing, cellular metabolism, and senescence, provide attractive models to explore the balancing act of insuring cellular survival yet accepting inevitable cellular demise, and determine the extent to which the “act” can be manipulated to alter aging.
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