Abstract
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Highlights
This Special Issue of Toxins, entitled “Cellular Entry of Binary and Pore-Forming Bacterial Toxins,” gives a sense of the recent advances in characterizing the functional and structural aspects of this broad scientific problem that goes beyond the classical field of toxinology and microbiology and spills into the general areas of biochemistry, biophysics, and molecular and cell biology
Key players often undergo profound conformational changes, both in aqueous [5] and membranous environments [1,2]. Characterizing these functionally important conformational changes is a prerequisite for deciphering the mechanisms of cellular entry on a molecular level
Several studies presented in this Special Issue either explicitly describe the formation of the water-filled protein structures that span the lipid-bilayer or implicitly evoke such structures, as a required part of the cellular entry mechanism
Summary
This Special Issue of Toxins, entitled “Cellular Entry of Binary and Pore-Forming Bacterial Toxins,” gives a sense of the recent advances in characterizing the functional and structural aspects of this broad scientific problem that goes beyond the classical field of toxinology and microbiology and spills into the general areas of biochemistry, biophysics, and molecular and cell biology. The contributions to this Special Issue include several experimental articles, employing sophisticated techniques to gain important insights into the mechanism of cellular entry [1,2,3,4,5,6]; a thought-provoking perspective comment [7]; and two conceptual reviews, one on apicomplexan pore-forming toxins [8] and one on clostridial binary toxins [9].
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