Abstract
Introduction: Post-lumpectomy wound fluid (seroma) contains many proteins from tumor bed due to physiologic answer to operation and wound healing process. Some cellular tests had been performed on different types of breast cancer (BC) cell lines and normal cell line while treated with seroma. Materials and Methods: The wound fluid samples were collected from BC patients. The human BC cell lines included MCF-7, MDA-MB-231 as well as normal non-tumorigenic epithelial cell line (MCF-10). Results: Seroma could inhibit various cancer cells proliferation pattern in comparison with the normal cell. Concerning the cell death, aggressive MDA-MB-231 cells were put into the apoptosis process. Besides, seroma could decrease colony count and size and changed the clone morphology from holoclone to paraclone. Regarding the invasion assay, seroma significantly inhibited cell motility. Conclusion: By remaining in tumor bed, seroma can induce inhibitory pattern of proliferation, and change the morphology of cancer cell colony and cell motility, consequently leading to positive impact on patients who suffer from cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
