Abstract
In the present work, Monte Carlo code MCNPX was used to determine the cellular dosimetric parameter; cellular S-values for frequently used radionuclides in targeted radionuclide therapy including 32P, 89Sr, 90Y, 117mSn, 153Sm, 166Ho, 170Tm, 177Lu, 186Re and 188Re. We considered the effect of some factors such as cell size, radiation subcellular localization and chemical composition on cellular S-values. The cells were defined as two concentric spheres and the radionuclides were assumed to be uniformly distributed in one of the cell compartments including cell surface (CS), cytoplasm (Cy), and nucleus (N). A comparison between MCNPX results with obtained MIRDcell values was performed. Deviations between MCNPX and MIRDcell were found to be less than ∼15% for self-absorption, in the cases of S(C ← C) and S(N ← N) values whereas discrepancies in S-values increased up to ∼22% for C ← CS and ∼28% for N ← Cy and N ← CS. The results showed a significant change with increasing the cell and cell nucleus size. For a given radionuclide, with increasing radii, S-values decreased in all compartments. For a given radius of the cell and nucleus, low energy radionuclides had higher S-values. For all source-target combinations, 153Sm and 90Y had the highest and lowest S-values, respectively.
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