Abstract
Anatomical, histological and karyological analyses on various somatic tissues from four artificially assembled XX/XY mouse chimeras were carried out in an attempt to determine the possible mechanism of sex differentiation in sex-chromosome chimeric mice. The data obtained from the present experiment suggest that genetic sex of various body cells has no bearing on the host's phenotypic sex, at least in mice. The analysis of the experimental data available in the literature and from the present experiment allowed the authors to postulate a possible mechanism for sex-determination in mammals. According to this model, the male- and female-determining factors of the sex chromosomes do not assert their influences on gonadal differentiation through either the somatic or the germinal elements of the primordial gonads alone. Rather there is an interaction of the sex constitution of both cell types; that is, the primordial germ cells and the blastema cells of the gonadal ridges play complementary roles in gonadal differentiation, and the final composition of the gonad is determined by thresholds of these factors.
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Schedule a callMore From: Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie
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