Abstract
Medulloblastoma is the most common primitive intracranial malignancy in childhood. We examined 28 cases (35 specimens) of medulloblastoma to elucidate the pathological features of this tumor. Although Homer Wright rosettes, pale islands, and dark and light areas characterize this tumor in most cases, several cases did not show any of these features. As the dark areas had more tumor cells than the light areas and were abundant in blood vessels and reactive astrocytes, they may have appeared darker. About one third of the specimens showed tumor cell immunoreactivities for neuronal markers, but only 2 reacted with glial markers. The light areas showed lower staining index values for proliferating markers than the dark areas. As cases showing Homer Wright rosettes and/or light and dark areas had good outcomes, these histological features are of potential prognostic importance.
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