Abstract
Isolated spleen cells of mouse have been used for the investigation of antibodies against sheep red blood cells (SRBC)1 either in the hemolytic plaque technique described by Jerne et al or the rosette formation test described by Zaalberg.2 However, rosette formation requires only the presence of receptor on the surface of the rosette forming cell (RFC), in contrast to the fact that the plaque formation requires the secretion and diffusion of antibody.3 So the RFC can be not only B cell but also T cell, but the plaque forming cell is always B cell. There have been many controversial reports about the nature and number of mouse spleen RFCs due to the variations in the affinities of the receptors of RFCs.
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