Abstract
Testicular damage was produced in rats by the intraperitoneal administration of manganese chloride (8 mg/kg) daily for a period of 180 days. Histopathological examination performed at 120 days showed oedema and congestion, at 150 days, degeneration of spermatids in about one third of the seminiferous tubules and subsequently at 180 days, about 50 per cent of seminiferous tubules were degenerated in all the animals. It is suggested that manganese possibly has a specific direct action on the spermatogenic epithelium.
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