Abstract
Cellular angiofibroma (CA)is a rare benign mesenchymal tumor. In women, it occurs mainly in the vulvovaginal region, with vulvar location in 70% of the cases. Its clinical presentation is nonspecific and similar to several other vulvar tumors of different cellular origins. Thus, its histological and immunohistochemical features allow distinction from other tumors. Cellular angiofibromas have good prognosis, despite some risk of relapse. The authors present the case of a 49-year-old woman with a bulky right vulvar lesion, for which the preoperative diagnosis was a Bartholin cyst, but the histological and immunohistochemical evaluation yielded a CA.
Highlights
Cellular angiofibroma (CA) is a rare benign tumor, first described in 1997 by Nucci et al.[1]. It is derived from the mesenchymal cells of the blood vessels in superficial soft tissue, and it occurs predominantly in the distal genital tract of both genders: vulvovaginal region in women and inguinoscrotal region in men.[2,3,4]
There was no Mesenchymal tumors in the vulvovaginal region are relatively rare, and they can be either non-specific tumors and have a more generalized distribution, such as those arising from smooth muscle, vessels, or neural cells, or they can have a predisposition to occur in the vulvovaginal region, such as aggressive angiomyxoma, angiomyofibroblastoma, or CA.[4,6]
Cellular angiofibroma is a rare benign tumor that originates from the mesenchymal cells of the blood vessels in superficial soft tissue.[2]
Summary
Cellular angiofibroma (CA) is a rare benign tumor, first described in 1997 by Nucci et al.[1]. Cellular angiofibroma lesions are characterized by occurring in middle-aged women (fifth decade of life) but later in men (seventh decade of life).[2,3] Usually, CAs are small sized (< 3 cm), painless, and well-circumscribed tumors. They have a slow growth, and, benign, there are a few cases of focal invasion and a case of tumor recurrence reported in the literature.[4,5] Still, they have not yet been associated with aggressive clinical behavior.[4,5,6,7].
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