Cellular and Molecular Mechanism of Liver Fibrosis: A Critical Insight

Abstract

Diseases are there, some are curable but certain diseases are life threatening. The dreadfulness of liver fibrosis created much attention in 21st century among pharmaceutical researchers. Usually liver fibrosis is asymptomatic and patients with advanced cirrhosis symptoms will have limited scope for reversibility. Recognition of asymptomatic individuals by considering them as critical is the fundamental step to control the liver-related morbidity and mortality. By reviewing the previous mortality analysis around the globe it is reported that liver fibrosis is the second leading cause of mortality in US, fifth most common cause of death in Germany, UK as well as tenth most frequent cause of fatality in India and around 10 lakh patients are diagnosed globally in every year. Liver fibrosis often leads to cirrhosis, hepatocellular carcinoma and progress towards liver failure which results due to excessive deposition of extracellular matrix (ECM) proteins, especially collagen type-1 contributed by hepatic stellate cells. The current study is based on for analyzing the molecular basis of liver fibrosis so that, it will be helpful for finding its route cause in cellular level which will guide as a future direction for developing new theranostic approaches for the early diagnosis of liver fibrosis.