Abstract
Abstract: Human movement is a complex and multifactorial process due to the interaction between the body and the environment. Movement is the result of activities of all the structures that make up a joint (i.e., ligaments, tendons, muscles, fascicles, blood vessels, nerves, etc.) and of the control actions of the nervous system on them. Therefore, many pathological conditions can affect the Neu-ro-Myo-Arthro-Kinetic System (NMAK). Osteoarthritis (OA) is the degenerative form of arthritis with a high incidence and a pro-longed course that affects articular and periarticular tissues such as articular cartilage, subchondral bone, and synovium, a degen-erative consequence. Instead, Rheumatoid arthritis (RA) is an immune-mediated synovial disease caused by a complex interaction between genetic and environmental factors. This review aims to compare Osteoar-thritis (OA) and Rheumatoid Arthritis (RA) in terms of pathogenesis and microenvironment and determine the main changes in a joint microenvironment regarding immunological defense elements and bioenergetics which can explain the pathological development with new thera-peutical opportunities. Keywords: Osteoarthritis (OA); Rheumatoid arthritis (RA); Homeostatic imbalances; Microenvironment
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
