Abstract
The availability of immunological and molecular probes to identify the various hormones has provided new tools to examine the mechanisms that govern the differentiation of pancreatic islet cells. From the perspective of a developmental biologist, the fundamental questions regarding the endocrine pancreas revolve around the role of genetic and epigenetic signals on differentiation of islet cells and on stability and/or plasticity of the differentiated phenotype. This chapter examines recent advances on these issues and describes the areas that remain to be explored. It describes the studies that relied on immunohistochemical techniques used to visualize one or more antigens in the same tissue sections. In other instances, immunohistochemistry was combined with autoradiography.
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