Abstract
EAE has been widely studied as a possible model for human demyelinative disease. It can be readily induced in several strains of rats by a single injection of spinal cord or encephalitogenic basic protein emulsified in complete Freund’s adjuvant (CFA). We have previously reported that AO rats always exhibited significantly lower susceptibility to the induction of EAE when compared with Lewis rats (1). In an attempt to delineate the mechanisms of the relative resistance to the induction of EAE in AO rats we studied comparatively the cellular requirements for the induction of EAE in Lewis, AO and Dark August (DA) rats. Further, we have undertaken a study of susceptibility to EAE in AO and DA rats, their F1 hybrids and animals of backcross generations in order to establish possible genetic determinants of the resistance to EAE in AO rats.KeywordsBasic ProteinExperimental Allergic EncephalomyelitisRelative ResistanceBackcross GenerationSuppressor Cell ActivityThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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