Cellular actions of insulin-like growth factor binding protein-3.

Abstract

Insulin-like growth factor I (IGF-I) plays a major role in regulating growth of cells in vivo and in vitro (1). IGF-I initiates metabolic and mitogenic processes in a wide variety of cell types by binding to specific type I IGF receptors in the plasma membrane (2). In addition, recent evidence suggests that association of IGF-I with distinct binding proteins present in extracellular fluids plays a pivotal role in determining IGF-I availability and bioactivity (3,4).KeywordsHuman FibroblastPreincubation PeriodBovine FibroblastThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.