Abstract
A new method for applying solid stress to aggregates of cells is shedding light on the impact of mechanical forces on cancer cells.
Highlights
Related research article Dolega ME, Monnier S, Brunel B, Joanny JF, Recho P, Cappello G. 2021
Much of our knowledge about solid stress and its impact on tumor development stems from research on three-dimensional aggregates of cancer cells grown in the laboratory
The small dextran molecules were able to infiltrate the extracellular matrix of the spheroids, thereby applying osmotic pressure on the single cells within
Summary
Related research article Dolega ME, Monnier S, Brunel B, Joanny JF, Recho P, Cappello G. 2021. Increasing evidence suggests that the physical interactions between cancer cells and their microenvironment affect the signals that regulate their growth and spread. Much of our knowledge about solid stress and its impact on tumor development stems from research on three-dimensional aggregates of cancer cells grown in the laboratory.
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