Abstract
Experimental models of human tissues and disease phenotypes frequently rely upon immortalized cell lines, which are easily accessible and simple to use due to their infinite capability of cell division. For decades, cell lines have been used to investigate cellular mechanisms of disease and the efficacy of drugs, most prominently for human cancers. However, the large body of knowledge with respect to human cell lines exists primarily in an unstructured fashion, that is, as free text in the scientific literature. Here we present CellLineMiner, a novel text mining-based web database that provides a comprehensive view of human cell line knowledge. The application offers a simple search in all indexed cell lines, accompanied by a rapid display of all identified literature associations. The CellLineMiner is intended to serve as a knowledge resource companion to the cellular model systems used in biomedical research.AvailabilityCellLineMiner is accessible at http://dev.pubgene.com/cellmine
Highlights
The scientific literature contains extensive reports aboutImmortalized cell lines represent powerful model systems in functional relationships between specific cell lines and other experimental biomedical research – they have an indefinite biomedical properties, such as drugs, diseases and biological growth capability, they can be frozen for decades, and shared processes
There is no simple means by which one lines still constitute a fundamental tool in drug development can query cell line names and retrieve the most relevant studies and in unraveling the cellular mechanisms of many biomedical concepts in a structured fashion
Most cell lines are available through bioresource providers or as a knowledge resource companion to the cellular model cell line banks, such as the American Type Culture Collection systems used in biomedical research
Summary
The scientific literature contains extensive reports aboutImmortalized cell lines represent powerful model systems in functional relationships between specific cell lines and other experimental biomedical research – they have an indefinite biomedical properties, such as drugs, diseases and biological growth capability, they can be frozen for decades, and shared processes. There is no simple means by which one lines still constitute a fundamental tool in drug development can query cell line names and retrieve the most relevant studies and in unraveling the cellular mechanisms of many biomedical concepts in a structured fashion. Most cell lines are available through bioresource providers or as a knowledge resource companion to the cellular model cell line banks, such as the American Type Culture Collection systems used in biomedical research.
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