Cell wall glucans of fungi. A review

Abstract

Glucans are the most abundant polysaccharides in the cell walls of fungi, and their structures are highly variable. Accordingly, their glucose moieties may be joined through either or both alpha (α) or beta (β) linkages, they are either lineal or branched, and amorphous or microfibrillar. Alpha 1,3 glucans sensu strictu (pseudonigerans) are the most abundant alpha glucans present in the cell walls of fungi, being restricted to dikarya. They exist in the form of structural microfibrils that provide resistance to the cell wall. The structure of beta glucans is more complex. They are linear or branched, and contain mostly β 1,3 and β 1,6 linkages, existing in the form of microfibrils. Together with chitin they constitute the most important structural components of fungal cell walls. They are the most abundant components of the cell walls in members of all fungal phyla, with the exception of Microsporidia, where they are absent.Taking into consideration the importance of glucans in the structure and physiology of the fungi, in the present review we describe the following aspects of these polysaccharides: i) types and distribution of fungal glucans, ii) their structure, iii) their roles, iv) the mechanism of synthesis of the most important ones, and v) the phylogentic relationships of the enzymes involved in their synthesis.