Abstract
Treatment of HeLa S-3 cells with excess thymidine (2 mM) caused blocking of DNA synthesis, which resulted in a synchronization of the cells after removal of thymidine. Continued synthesis of RNA and protein suggests an “unbalanced growth” syndrome with a deficiency in the deoxycytidylate moiety analogous to states induced by 1-β- d-arabinofuranosyl cytosine or 5-fluorodeoxyuridine. Exposure of cells to excess deoxyadenosine produces a loss of cell viability accompanied by an inhibition of DNA, RNA, and protein synthesis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
