Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples.

Abstract

Evidence suggests that the hippocampus conveys memory-related neural patterns across distributed cortical circuits during high-frequency oscillations called sharp-wave ripples (SWRs). We investigate how circuit activity in the retrosplenial cortex (RSC), a primary hippocampal target, could aid in processing SWR-related input. Using patch-clamp recordings from awake mice, we find that SWR-aligned membrane potential modulation is widespread but weak, and that spiking responses are sparse. However, using cell-type-specific two-photon Ca2+ imaging and optogenetics, we show that, 1-2s before SWRs, superficial inhibition and thalamocortical input in RSC is reduced. We propose that pyramidal dendrites experience decreased local inhibition and subcortical interference in a seconds-long time window preceding SWRs. This may aid communication of weak and sparse SWR-aligned excitation between the hippocampus and neocortex and promote the strengthening of memory-related connections.