Abstract
This chapter discusses the cell-to-cell communication in peptide target cells of anterior pituitary. It also describes intercellular communication in the anterior pituitary by preparing highly enriched populations of the various pituitary cell types and the influence of one of these cell types on the activity of others in three-dimensional cell cultures (also known as reaggregates, aggregates, or aggregate cell cultures). The existence of regulatory signals from one cell type to another was estimated from the change in secretory response induced by the co-aggregation of both cell types. Secretory responses were followed as a function of time in a perifusion system in that aggregates remained functional for periods up to several weeks. The three-dimensional configuration and tissue just as the organization of the cells in the aggregate most likely favor the expression of these communication systems. As has been shown for brain cells, aggregates express various functional and morphogenetic capabilities that are very similar to the in vivo capabilities of the tissue.
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