Abstract
The colony stimulating factor granulocyte (G-CSF) is a glycoprotein capable of promoting the survival, proliferation and differentiation of hematopoietic cells. Studies demonstrate the cytoprotective action of G-CSF against renal injury by ischemia/reperfusion injury in murine models. But the literature is still controversial in relation to the risk of worsening renal function after useG-CSF, which motivated the study to elucidate possible interference on the renal function of the treated animals.
Highlights
The colony stimulating factor granulocyte (G-CSF) is a glycoprotein capable of promoting the survival, proliferation and differentiation of hematopoietic cells
There was no significant difference between the values of creatinine clearance, proteinuria and Urea, among groups C, G-CSF at a dose of 10 (G10) and G50
There was no impairment of renal function in animals treated at doses of 10 and 50 mg / kg / per 5 days
Summary
The colony stimulating factor granulocyte (G-CSF) is a glycoprotein capable of promoting the survival, proliferation and differentiation of hematopoietic cells. Studies demonstrate the cytoprotective action of G-CSF against renal injury by ischemia/reperfusion injury in murine models. The literature is still controversial in relation to the risk of worsening renal function after useG-CSF, which motivated the study to elucidate possible interference on the renal function of the treated animals. In urine volume after 24 hours treatment with G-CSF. There was no significant difference between the values of creatinine clearance, proteinuria and Urea, among groups C, G10 and G50
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