Abstract
The surface energy of cells is the quantity which dominates certain physical interactions of cells such as adhesion to hydrophobic surfaces and phagocytosis. A linear relationship is derived relating the equilibrium constant obtained from phase partition in liquid-liquid systems with the surface energy difference obtained from contact-angle measurements. Using biphasic mixtures of Dextran and poly(ethylene glycol) in a medium of constant salt composition the expression is confirmed for transformed lymphocytic cell lines. The results demonstrate the importance of van der Waals' interactions in the phase-partition process, that phase partition can be used as a direct measure of cell surface hydrophobicity, and that the equilibrium constant of phase partition is directly related to the difference in the surface energy of the partitioned particle between the two phases.
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