Abstract
In vitro inhibition of cell migration/wound closure and cellular apoptosis was studied of four chloroform extract fractions of clove (Syzygium aromaticum L.) on human A549 and H1299 cancer cell lines. The flow cytometry analysis was carried out with A549 and H1299 cancer cell lines. The results indicated that chloroform extract fractions of clove showed inhibition of wound closure/cell migration of A549 and H1299 and induced apoptosis of H1299. This was demonstrated by calculating low wound closure percentage in cells; treated with these fractions as compared to control (70%). The morphological features of the nuclei of the cells treated with fractions indicated chromatin compression, nuclear shrinkage and apoptotic bodies formation, which pointed out towards death by apoptosis. The flow cytometer analysis of the treated cancer cells H1299 also revealed death due to the apoptosis. These results confirmed that the chloroform extract of clove bud may be used to treat lung cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
