Abstract
The macrophase-migration inhibition test was used to detect antitumor immunity in a syngeneic system: BALB/c mice immunized against a plasma cell tumor. Migration of peritoneal exudate cells, as well as spleen cells, was assayed. Migration of both cell populations was specifically inhibited in the presence of tumor cells and specifically immunized splenic lymphocytes. This reaction was mediated by a soluble factor that was demonstrated in the supernatant from mixtures of immune lymphocytes and tumor cells. An allogeneic system was tested as a positive control.
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