Abstract
Cell lysis and changes of shape were examined to elucidate the effects of injections on rat erythrocytes. Hemolysis did not occur within the range of pH 5.5-8.0 and 160-700 mOsm/kg in a period of 2 hrs at 37°C. Clear change of shape were not observed within the range of pH 7.0-8.0 and 280-300 mOsm/kg in a period of 2 hrs at 37°C by a scanning electron microstopy. Benzyl alcohol, ethyl alcohol and propylene glycol showed strong hemolytic activity at the concentration, regularly contained in injections. Benzyl alcohol produced internalization of erythrocytes ; however clear morphological change was not observed with ethyl alcohol or propylene glycol. The effects of other drugs or ingredients in injections were also examined.
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