Abstract
The review presents a discussion on articles and patents, describing new in vitro and in vivo models of pigmented or non-pigmented human cutaneous melanoma, received in NMRCO from the patients» metastases. Molecular genetic characteristics of the new models is supported by the arguments in addition to the given data and visual materials. The subjects of the discussed publications are 3 polyclonal cell lines, 2 subclones and 4 subcutaneous (s/c) xenografts in immunodeficient mice Balb/c nude. All the models are stored in Cryo Collection with xenografts at N.N. Blokhin NMRCO as well as in the Russian Collection of Cell Cultures of Vertebrae (RCCCV, St. Petersburg). This mini-collection is recommended for use in basic research of cutaneous melanoma and pre-clinical studies of anti-melanoma agents. The basis for these studies are the appropriate characteristics of the models, including cytological, immunologic, transplantation and molecular-genetic ones, as well as in vivo drug sensitivity to the corresponding target therapy.
Highlights
CELL LINES OF HUMAN MELANOMA AND THEIR XENOGRAFT WITH BRAF OR NRAS MUTATIONS A TARGETS FOR TARGETED THERAPY
The review presents a discussion on articles and patents, describing new in vitro and in vivo models of pigmented or non-pigmented human cutaneous melanoma, received in NMRCO from the patients» metastases
All the models are stored in Cryo Collection with xenografts at N
Summary
КЛЕТОЧНЫЕ ЛИНИИ МЕЛАНОМЫ ЧЕЛОВЕКА И ИХ КСЕНОГРАФТЫ С МУТАЦИЯМИ BRAF ИЛИ NRAS В КАЧЕСТВЕ МИШЕНЕЙ ДЛЯ ТАРГЕТНОЙ ТЕРАПИИ. В обзоре представлен свод статей и патентов, описывающих новые модели пигментированной или амеланотической меланомы кожи человека in vitro и in vivo, полученные в ФГБУ «НМИЦ онкологии им. The review presents a discussion on articles and patents, describing new in vitro and in vivo models of pigmented or non-pigmented human cutaneous melanoma, received in NMRCO from the patients» metastases. This mini-collection is recommended for use in basic research of cutaneous melanoma and pre-clinical studies of anti-melanoma agents. The basis for these studies are the appropriate characteristics of the models, including cytological, immunologic, transplantation and molecular-genetic ones, as well as in vivo drug sensitivity to the corresponding target therapy.
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